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Kinetic Stability Studies on Yttrium(III)−1,4,7,10- Tetraazacyclododecane-1,4,7,10-tetraacetic Acid by Free-Ion Selective Radiotracer Extraction

Denis Jurkin, Franz Josef Gildehaus, B. Wierczinski

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Abstract

Free-ion selective radiotracer extraction (FISRE) using no-carrier-added (90)Y has been applied to assess the dissociation kinetics of yttrium(III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Y-DOTA), a radiopharmaceutical precursor with a remarkable kinetic stability. In order to extend the operationally defined detection window, a complemental FISRE-based experiment has been successfully developed. Within a time frame of approximately 10 half-times of (90)Y (t(1/2) = 61.4 h), the complex Y-DOTA has been observed to form two kinetically distinguishable species with significantly different kinetic properties. The time-dependent speciation was measured to be sensitive to pH variations even in the neutral pH range (4.5-7.4) whereas the impact of ionic strength changes is negligible.

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What this paper is about

Free-ion selective radiotracer extraction (FISRE) using no-carrier-added (90)Y has been applied to assess the dissociation kinetics of yttrium(III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Y-DOTA), a radiopharmaceutical precursor with a remarkable kinetic stability. In order to extend the operationally defined detection window, a complemental FISRE-based experiment has been successfully developed. Within a time frame of approximately 10 half-times of (90)Y (t(1/2) = 61.4 h), the complex Y-DOTA has been observed to form two kinetically distinguishable species with significantly different kinetic properties. The time-dependent speciation was measured to be sensitive to pH variations even in the neutral pH range (4.5-7.4) whereas the impact of ionic strength changes is negligible.

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Available abstract

Free-ion selective radiotracer extraction (FISRE) using no-carrier-added (90)Y has been applied to assess the dissociation kinetics of yttrium(III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Y-DOTA), a radiopharmaceutical precursor with a remarkable kinetic stability. In order to extend the operationally defined detection window, a complemental FISRE-based experiment has been successfully developed. Within a time frame of approximately 10 half-times of (90)Y (t(1/2) = 61.4 h), the complex Y-DOTA has been observed to form two kinetically distinguishable species with significantly different kinetic properties. The time-dependent speciation was measured to be sensitive to pH variations even in the neutral pH range (4.5-7.4) whereas the impact of ionic strength changes is negligible.

Key concepts: DOTA, Chemistry, Yttrium, Ionic strength, Kinetics, Dissociation (chemistry), Kinetic energy, Ion

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Kinetic Stability Studies on Yttrium(III)−1,4,7,10- Tetraazacyclododecane-1,4,7,10-tetraacetic Acid by Free-Ion Selective Radiotracer Extraction — Research Paper | ScholarLens