1974•Acta Pharmacologica et ToxicologicaRequires access

The Formationin Vivoof 3,4‐Dihydroxyphenylalanine (DOPA) from 3‐Hydroxy‐DL‐phenylalanine (m‐Tyrosine)

Gunnar Hollunger, Sven‐Åke Persson

Abstract

Abstract:The formation of 3,4‐DOPA from m‐tyrosinein vivois demonstrated. The kinetic aspects of DOPA accumulation in the brain after central and peripheral inhibition of the 1‐aromatic amino acid decarboxylase are considered. It is concluded that the excess DOPA accumulation after administration of m‐tyrosine is due to the uptake from the blood of DOPA generated in the liver. This exogenous DOPA is shown to be much less exposed to brain decarboxylase than DOPA generated in the brain. The possibility that the pharmacological effects of m‐tyrosine can at least partly be explained by dopamine generation from DOPA is discussed.

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Key concepts: Tyrosine, Dihydroxyphenylalanine, Aromatic L-amino acid decarboxylase, Phenylalanine, In vivo, Decarboxylase inhibitor, Dopamine, Chemistry