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CEREBRAL ETIOLOGY OF THE ACUTE RESPIRATORY DISTRESS SYNDROME

Gerald S. Moss, Arthur A. Stein

Open publisher page 19 citations

Abstract

Beagles and rats were subjected to hemorrhage regimens that induced the pulmonary complex of the Acute Respiratory Distress Syndrome (ARDS) in 6:6 dogs and 7:8 rats. Pretreatment with diphenylhydantoin (DPH), 5 mg/kg 1-2 hours preceding hemorrhage, resulted in complete prevention of the lung lesions in 8:8 dogs. (P smaller than 0.005). It also provided significant (P smaller than 0.01) protection to 8:11 rats. We offer this as circumstantial evidence that the ARDS has a centrineurogenic etiology.

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What this paper is about

Beagles and rats were subjected to hemorrhage regimens that induced the pulmonary complex of the Acute Respiratory Distress Syndrome (ARDS) in 6:6 dogs and 7:8 rats. Pretreatment with diphenylhydantoin (DPH), 5 mg/kg 1-2 hours preceding hemorrhage, resulted in complete prevention of the lung lesions in 8:8 dogs. (P smaller than 0.005). It also provided significant (P smaller than 0.01) protection to 8:11 rats. We offer this as circumstantial evidence that the ARDS has a centrineurogenic etiology.

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OpenAlex reports 19 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Beagles and rats were subjected to hemorrhage regimens that induced the pulmonary complex of the Acute Respiratory Distress Syndrome (ARDS) in 6:6 dogs and 7:8 rats. Pretreatment with diphenylhydantoin (DPH), 5 mg/kg 1-2 hours preceding hemorrhage, resulted in complete prevention of the lung lesions in 8:8 dogs. (P smaller than 0.005). It also provided significant (P smaller than 0.01) protection to 8:11 rats. We offer this as circumstantial evidence that the ARDS has a centrineurogenic etiology.

Key concepts: ARDS, Etiology, Medicine, Acute respiratory distress, Respiratory distress, Circumstantial evidence, Pulmonary hemorrhage, Respiratory system

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