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1981•Scandinavian Journal of GastroenterologyRequires access

Serum Concentration of Pancreatic Polypeptide after Infusion of Histamine and the Effect of Cimetidine, Trimipramine, and Atropine in Man

O. Flaten, Thomas M. Bohman, J. Myren

Open publisher page 3 citations

Abstract

Histamine was given intravenously to eight human subjects, and the PP concentration in serum increased significantly from 14.8 (7.2-29.3) pM to 27.5 (9.6-39.3) pM and then decreased to the basal level. This histamine-induced PP release was not altered when trimipramine or cimetidine was given in addition to histamine. This PP release could not mediated through histamine-receptor mechanisms, and since atropine prevented this PP release, we conclude that the release of PP after histamine reflects a cholinergic stimulus.

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What this paper is about

Histamine was given intravenously to eight human subjects, and the PP concentration in serum increased significantly from 14.8 (7.2-29.3) pM to 27.5 (9.6-39.3) pM and then decreased to the basal level. This histamine-induced PP release was not altered when trimipramine or cimetidine was given in addition to histamine. This PP release could not mediated through histamine-receptor mechanisms, and since atropine prevented this PP release, we conclude that the release of PP after histamine reflects a cholinergic stimulus.

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Available abstract

Histamine was given intravenously to eight human subjects, and the PP concentration in serum increased significantly from 14.8 (7.2-29.3) pM to 27.5 (9.6-39.3) pM and then decreased to the basal level. This histamine-induced PP release was not altered when trimipramine or cimetidine was given in addition to histamine. This PP release could not mediated through histamine-receptor mechanisms, and since atropine prevented this PP release, we conclude that the release of PP after histamine reflects a cholinergic stimulus.

Key concepts: Cimetidine, Histamine, Atropine, Internal medicine, Endocrinology, Chemistry, Histamine H2 receptor, Cholinergic

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Serum Concentration of Pancreatic Polypeptide after Infusion of Histamine and the Effect of Cimetidine, Trimipramine, and Atropine in Man — Research Paper | ScholarLens