2014•Bioorganic & Medicinal Chemistry LettersOpen access

Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms

Andrew M. Haidle, Anna A. Zabierek, Kaleen K. Childers, Craig Rosenstein, Anjili Mathur, Michael D. Altman, Grace Hoyee Chan, Lin Sen Xu, Eric Scott Bachman, Jan-Rung Mo, Melaney Bouthillette, Thomas S. Rush, Paul A. Tempest, C. Gary Marshall, Jonathan R. Young

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Key concepts: Chemistry, Carboxamide, Bioisostere, Metabolic stability, Substituent, Thiophene, Ring (chemistry), In vivo