1991•Journal of the Neurological SciencesOpen access

Localization of mitochondrial DNA in normal and pathological muscle using immunological probes: A new approach to the study of mitochondrial myopathies

Francesca Andreetta, Hans-Jürgen Tritschler, Eric A. Schon, Salvatore DiMauro, Eduardo Bonilla

Abstract

We have studied the usefulness of anti-DNA antibodies to detect ragged-red fibers (RRF) in muscle biopsies from patients with mitochondrial myopathies. We have found that these antibodies are excellent probes for the localization of mitochondrial DNA (mtDNA) in RRF, and for the diagnosis of depletion of mtDNA in a newly described group of fatal myopathies of infancy.

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Key concepts: Mitochondrial DNA, Mitochondrial myopathy, Pathological, Mitochondrion, DNA, Antibody, Pathology, Biology