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1996•Acta CytologicaRequires access

Fine Needle Aspiration Cytology of Anaplastic Carcinoma with Osteoclastlike Giant Cells of the Thyroid

Ji Shin Lee, Min Cheol Lee, Chang Soo Park, Sang Woo Juhng

Open publisher page 16 citations

Abstract

BACKGROUND: Multinucleated giant cells of osteoclastlike appearance are seen in some anaplastic carcinomas, but only three cases in which the diagnosis was made by aspiration cytology are reported in the international medical literature. CASE: A 66-year-old female presented with a history of a palpable neck mass. The diagnosis of fine needle aspiration cytology was anaplastic thyroid carcinoma with osteoclastlike giant cells. Immunohistochemical staining and DNA ploidy analysis were done. CONCLUSION: Osteoclastlike giant cells have an origin different from that of the anaplastic component. DNA aneuploidy was noted in our case.

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BACKGROUND: Multinucleated giant cells of osteoclastlike appearance are seen in some anaplastic carcinomas, but only three cases in which the diagnosis was made by aspiration cytology are reported in the international medical literature. CASE: A 66-year-old female presented with a history of a palpable neck mass. The diagnosis of fine needle aspiration cytology was anaplastic thyroid carcinoma with osteoclastlike giant cells. Immunohistochemical staining and DNA ploidy analysis were done. CONCLUSION: Osteoclastlike giant cells have an origin different from that of the anaplastic component. DNA aneuploidy was noted in our case.

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Available abstract

BACKGROUND: Multinucleated giant cells of osteoclastlike appearance are seen in some anaplastic carcinomas, but only three cases in which the diagnosis was made by aspiration cytology are reported in the international medical literature. CASE: A 66-year-old female presented with a history of a palpable neck mass. The diagnosis of fine needle aspiration cytology was anaplastic thyroid carcinoma with osteoclastlike giant cells. Immunohistochemical staining and DNA ploidy analysis were done. CONCLUSION: Osteoclastlike giant cells have an origin different from that of the anaplastic component. DNA aneuploidy was noted in our case.

Key concepts: Giant cell, Medicine, Cytology, Pathology, Anaplastic carcinoma, Fine-needle aspiration, Fine needle aspiration cytology, Neck mass

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