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The Synthesis of Spin - Labeled Imipramine Analogs

D. Kikelj, Slavko Pečar, B. Debeljak, D. Karba, Aleš Krbavčić

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Abstract

Spin - labeled drugs have proved to be a valuable investigative tool in the study of drug - membrane and drug - receptor interactions1. Since we are interested in the membrane action of tricyclic antidepressants, we have decided to synthetize some spin - labeled analogs of imipramine. These compounds are expected to be useful paramagnetic probes which could be used in further elucidation of interactions of tricyclic antidepressants with membranes and receptors.

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What this paper is about

Spin - labeled drugs have proved to be a valuable investigative tool in the study of drug - membrane and drug - receptor interactions1. Since we are interested in the membrane action of tricyclic antidepressants, we have decided to synthetize some spin - labeled analogs of imipramine. These compounds are expected to be useful paramagnetic probes which could be used in further elucidation of interactions of tricyclic antidepressants with membranes and receptors.

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Available abstract

Spin - labeled drugs have proved to be a valuable investigative tool in the study of drug - membrane and drug - receptor interactions1. Since we are interested in the membrane action of tricyclic antidepressants, we have decided to synthetize some spin - labeled analogs of imipramine. These compounds are expected to be useful paramagnetic probes which could be used in further elucidation of interactions of tricyclic antidepressants with membranes and receptors.

Key concepts: Tricyclic, Imipramine, Chemistry, Membrane, Spin label, Drug, Site-directed spin labeling, Drug action

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