1982•Journal of General VirologyRequires access

Mumps Virus-persistently Infected Cell Cultures Release Defective Interfering Virus Particles

O. G. Andzhaparidze, Yu. S. Boriskin, N. N. Bogomolova, I. D. Drynov

Abstract

Summary Two human cell cultures, HEp-2 and L-41, persistently infected with mumps virus, produced small amounts of slowly replicating small-plaque infectious virus and detectable amounts of defective interfering virus particles which were similar to standard mumps virus in polypeptide composition, contained subgenomic size RNAs and interfered with standard mumps virus replication in susceptible cells.

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Key concepts: Mumps virus, Virology, Biology, Virus, Viral Interference, Subgenomic mRNA, Cell culture, Viral replication