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BIOLOGICAL ACTIVITY OF MEDROGESTONE: A NEW ORALLY ACTIVE PROGESTIN

Csaba Révész, C. I. Chappel

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Abstract

Summary. A new synthetic orally active progestational agent 'Medrogestone' was investigated and its activity compared to progesterone and medroxyprogesterone acetate (map). Medrogestone fulfils the criteria of a pure gestagen, it has a spectrum of biological activity similar to that of progesterone but unlike progesterone, it is orally active. Medrogestone is free of undesirable side effects in experimental animals. It is being investigated clinically as an oral progestin (Carter, Faucher & Greenblatt, 1964).

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Summary. A new synthetic orally active progestational agent 'Medrogestone' was investigated and its activity compared to progesterone and medroxyprogesterone acetate (map). Medrogestone fulfils the criteria of a pure gestagen, it has a spectrum of biological activity similar to that of progesterone but unlike progesterone, it is orally active. Medrogestone is free of undesirable side effects in experimental animals. It is being investigated clinically as an oral progestin (Carter, Faucher & Greenblatt, 1964).

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Available abstract

Summary. A new synthetic orally active progestational agent 'Medrogestone' was investigated and its activity compared to progesterone and medroxyprogesterone acetate (map). Medrogestone fulfils the criteria of a pure gestagen, it has a spectrum of biological activity similar to that of progesterone but unlike progesterone, it is orally active. Medrogestone is free of undesirable side effects in experimental animals. It is being investigated clinically as an oral progestin (Carter, Faucher & Greenblatt, 1964).

Key concepts: Progestin, Medroxyprogesterone acetate, Orally active, Biological activity, Medroxyprogesterone, Pharmacology, Chemistry, Medicine

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