2009•RespirationRequires access
Selective Inhibition of Cough and Bronchoconstriction in Conscious Guinea Pigs
K. Forsberg, Jessica Karlsson, C. Zackrisson, C. G. A. Persson
Open publisher page 27 citations
Abstract
In guinea-pigs citric acid-induced cough and bronchoconstriction were inhibited by beta 2-agonist and xanthine drugs. Lidocaine inhibited only cough. Cromoglycate and ipratropium bromide inhibited only bronchoconstriction. We conclude that cough and bronchoconstriction in guinea-pigs are distinct reflexes and that the inhibitory pharmacology of these airway reflexes may agree in many respects, with that observed in asthmatic subjects.