1997•Journal of obstetrics and gynaecology researchRequires access
The Behavior of Endometrial Hyperplasia: A Prospective Study
Naoki Terakawa, Junzo Kigawa, Yuji Taketani, Hiroyuki Yoshikawa, Akira Yajima, Kiichiro Noda, Hiroji Okada, Junzo Kato, M Yakushiji, Osamu Tanizawa, Seiichiro Fujimoto, Shiro Nozawa, Takeshi Takahashi, Katsuhiko Hasumi, Nobuyuki Furuhashi, Toshihiro Aono, Atsuhiko Sakamoto, Masakuni Furusato, Endometrial Hyperplasia Study Group
Open publisher page 101 citations
Abstract
OBJECTIVE: To clarify the behavior of endometrial hyperplasia in a prospective study. METHOD: Fifty-one patients with endometrial hyperplasia were followed up for 6 months. Samples of endometrial tissues were taken by uterine endometrial biopsy every 4 weeks during the first 3 months and at the end of follow-up. RESULTS: In 69% (35/51) of the patients histological picture of the endometrium became normal during the observation period. The lesions persisted in 17% (6/35) of the patients with simple hyperplasia, in 25% (1/4) of those with complex hyperplasia, in 14% (1/7) of those with simple atypical hyperplasia, and in 80% (4/5) of the patients with complex atypical hyperplasia. In the remaining 3 patients with simple hyperplasia, the lesions progressed to complex atypical hyperplasia by the end of follow-up, after showing a normal endometrium. CONCLUSION: Most cases of endometrial hyperplasia, except for complex atypical hyperplasia, disappeared spontaneously within a short period of time.