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Enantioselective Friedel-Crafts Alkylation Using Chiral Phosphoric Acid

Y. Sheng, Qingqing Gu, An‐Jiang Zhang, Shu‐Li You

Abstract

Significance A highly enantioselective Brønsted acid-catalyzed Friedel-Crafts reaction of pyrroles and nitroolefins is described. The authors reported the efficient enantioselective alkylation of pyrroles for a wide range of substrates using chiral phosphoric acid 1 . This work is the first example of an enantioselective organocatalytic Friedel-Crafts reaction of this substrate combination.

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Available abstract

Key concepts: Enantioselective synthesis, Friedel–Crafts reaction, Phosphoric acid, Chemistry, Alkylation, Brønsted–Lowry acid–base theory, Organic chemistry, Organocatalysis