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Evaluation of a New Confirmatory Assay for Antibodies against Lymphadenopathy‐Associated Virus (LAV)/Human T‐Lymphotropic Virus Type III (HTLV III)

Jochen Abb

Abstract

We have evaluated a newly developed competitive enzyme immunoassay for the specific detection of antibodies against LAV/HTLV III envelope and core proteins. Comparative studies of sera from high-risk donors showed complete concordance between the results of the confirmatory enzyme immunoassay and immunoblot or indirect immunofluorescence techniques. Studies of sera from blood donors with a repeatedly reactive screening test for anti-LAV/HTLV III demonstrated two specimens which were positive by the confirmatory enzyme immunoassay and negative or indeterminable by immunoblotting and immunofluorescence.

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Available abstract

Key concepts: Immunoassay, Immunofluorescence, Virology, Human T-lymphotropic virus, Antibody, Virus, Immunology, Medicine