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TunesPhos/1,2-Diamine-Ru(II) Complex Catalyzed Hydrogenation of Ketones

Wentao Li, X. Sun, Le Zhou, Gang Hou, Shichao Yu, Xue Zhang

Abstract

Significance TunePhos-type chiral diphosphine ligands have been demonstrated previously to be highly effective in the asymmetric hydrogenation of N-substituted allylphthalimides and α-keto esters. In this report, TunesPhos/1,2-diamine-ruthenium(II) complexes catalyzed the asymmetric hydrogenation of various aromatic ketones with very high reactivity and excellent enantioselectivities.

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Available abstract

Key concepts: Chemistry, Ruthenium, Diamine, Catalysis, Asymmetric hydrogenation, Noyori asymmetric hydrogenation, Reactivity (psychology), Organic chemistry