1987•Chemical and Pharmaceutical BulletinOpen access
Intestinal absorption of tocopherol in beagle dog and effect of dosage form.
Tadakazu Tokumura, Yoshiharu Machida, Yuki Tsushima, Masanori Kayano, Tsuneji Nagai
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Abstract
Intestinal absorption of d-α-tocopherol from four model preparations was investigated after oral administration to beagle dogs. The bioavailability of d-α-tocopherol from the model preparations was evaluated by determination of the plasma level after oral administration. It was found that the absorption of d-α-tocopherol was not affected by food, and that the difference in dosage forms caused a difference in bioavailability. The tablet showed lower availability than capsules filled with oily solution.
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