Inosin‐N(1)‐oxid‐Nucleotide als Komplexbildner. I. Darstellung von Inosin‐N(1)‐oxid und dessen 5′‐Monophosphat aus Adenosin‐N(1)‐oxid und dessen 5'‐Monophosphat durch Desaminierung mit Nitrosylchlorid
Helmut Sigel, Hans Herbert Brintzinger
Abstract
Helmut Sigel, Hans Herbert Brintzinger
Abstract
Abstract The hitherto unknown compounds inosine N(1)‐oxide and inosine N(1)‐oxide 5′‐monophosphate have been synthesized by deamination of adenosine N(1)‐oxide and its monophosphate with nitrosyl chloride in dimethylformamide. This method is also useful for deamination of adenosine, adenosine 5′‐monophosphate and adenosine 5′‐triphosphate.
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Abstract The hitherto unknown compounds inosine N(1)‐oxide and inosine N(1)‐oxide 5′‐monophosphate have been synthesized by deamination of adenosine N(1)‐oxide and its monophosphate with nitrosyl chloride in dimethylformamide. This method is also useful for deamination of adenosine, adenosine 5′‐monophosphate and adenosine 5′‐triphosphate.
Key concepts: Chemistry, Deamination, Inosine, Adenosine, Nucleotide, Adenosine monophosphate, Dimethylformamide, Medicinal chemistry