2005•Journal of Gastroenterology and HepatologyRequires access

CYP2C19 genotype and the PPIs – focus on rabeprazole

Paul Lim, Khean‐Lee Goh, Benjamin CY Wong

Abstract

Amongst all the proton pump inhibitors (PPI), the hepatic metabolism of rabeprazole is least dependent on the CYP4502C19 system. Rabeprazole is therefore the PPI least affected by CYP4502C19 genetic polymorphism. This unique feature of rabeprazole complements rabeprazole's fast onset of action, and may lead to profound and consistent inhibition of gastric acid secretion in the treatment of acid-related disorders.

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Key concepts: Rabeprazole, CYP2C19, Medicine, Proton-pump inhibitor, Gastric acid, Genotype, Gastroenterology, Internal medicine