1975•Journal of EndocrinologyRequires access

DYNAMICS OF INSULIN RELEASE BY PERFUSED HAMSTER ( MESOCRICETUS AURATUS ) PANCREASES: EFFECTS OF HYPOPHYSECTOMY, BOVINE AND HUMAN GROWTH HORMONE, AND PROLACTIN

DONALD L. CURRYt, Leslie L. Bennett, Choh Hao Li

Abstract

The hamster exhibits a biphasic pattern of insulin secretion; however, the dynamic response differs qualitatively from that of the rat in that there is a steady-state second release phase. A marked attenuation of insulin secretion as a result of hypophysectomy was observed after 3 weeks, but not after 2 weeks. This depression of insulin secretion was restored to near or above normal levels by bovine growth hormone, human growth hormone, and prolactin.

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Key concepts: Endocrinology, Internal medicine, Hypophysectomy, Prolactin, Hamster, Insulin, Mesocricetus, Hormone