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2005•Animal Health Research ReviewsOpen access

Genetic diversity of Anaplasma species major surface proteins and implications for anaplasmosis serodiagnosis and vaccine development

José de la Fuente, Ala E. Lew, Hans Lutz, Marina L. Meli, Regina Hofmann‐Lehmann, Varda Shkap, T. Molad, Atílio J. Mangold, Consuelo Almazán, Victoria Naranjo, Christian Gortázar, Alessandra Torina, S. Caracappà, Ana L. García‐Pérez, Marta Barral, Beatriz Oporto, Luigi Ceci, Grazia Carelli, Edmour F. Blouin, Katherine M. Kocan

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Abstract

The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several pathogens of veterinary and human medical importance. An understanding of the diversity of Anaplasma major surface proteins (MSPs), including those MSPs that modulate infection, development of persistent infections, and transmission of pathogens by ticks, is derived in part, by characterization and phylogenetic analyses of geographic strains. Information concerning the genetic diversity of Anaplasma spp. MSPs will likely influence the development of serodiagnostic assays and vaccine strategies for the control of anaplasmosis.

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What this paper is about

The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several pathogens of veterinary and human medical importance. An understanding of the diversity of Anaplasma major surface proteins (MSPs), including those MSPs that modulate infection, development of persistent infections, and transmission of pathogens by ticks, is derived in part, by characterization and phylogenetic analyses of geographic strains. Information concerning the genetic diversity of Anaplasma spp. MSPs will likely influence the development of serodiagnostic assays and vaccine strategies for the control of anaplasmosis.

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Available abstract

The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several pathogens of veterinary and human medical importance. An understanding of the diversity of Anaplasma major surface proteins (MSPs), including those MSPs that modulate infection, development of persistent infections, and transmission of pathogens by ticks, is derived in part, by characterization and phylogenetic analyses of geographic strains. Information concerning the genetic diversity of Anaplasma spp. MSPs will likely influence the development of serodiagnostic assays and vaccine strategies for the control of anaplasmosis.

Key concepts: Anaplasmataceae, Anaplasmosis, Anaplasma, Biology, Genetic diversity, Tick-borne disease, Rickettsiales, Phylogenetic tree

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