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Hypogonadotropic Hypogonadism with Anosmia (Kallmann's Syndrome) Unresponsive to Clomiphene Citrate

Werner G. Schroffner, EUGENE D. FURTH

Open publisher page 29 citations

Abstract

A patient with hypogonadotropic hypogonadism and anosmia (Kallmann's syndrome) is reported. Plasma levels of pituitary follicle stimulating and luteinizing hormones, as determined by radioimmunoassay, were low, and did not rise following administration of clomiphene citrate for 6 weeks. Anosmia in the father supports an autosomal mode of inheritance in this case.

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What this paper is about

A patient with hypogonadotropic hypogonadism and anosmia (Kallmann's syndrome) is reported. Plasma levels of pituitary follicle stimulating and luteinizing hormones, as determined by radioimmunoassay, were low, and did not rise following administration of clomiphene citrate for 6 weeks. Anosmia in the father supports an autosomal mode of inheritance in this case.

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OpenAlex reports 29 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A patient with hypogonadotropic hypogonadism and anosmia (Kallmann's syndrome) is reported. Plasma levels of pituitary follicle stimulating and luteinizing hormones, as determined by radioimmunoassay, were low, and did not rise following administration of clomiphene citrate for 6 weeks. Anosmia in the father supports an autosomal mode of inheritance in this case.

Key concepts: Anosmia, Hypogonadotropic hypogonadism, Kallmann syndrome, Endocrinology, Internal medicine, Luteinizing hormone, Hyposmia, Delayed puberty

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