1995•International Journal of ImmunogeneticsRequires access

A NOVEL TaqI/DQA RFLP ASSOCIATED WITH HLA‐DR9, DQ9 (DQA1* 0302)

Carlos Vilches, Rosario de Pablo, R. Solias, Rosario Martı́n, María José Herrero, María Elena Moreno, M. Kreisler

Abstract

A new TaqI/DQA restriction fragment length polymorphism (RFLP) has been found in two Spanish Caucasoid individuals. The novel polymorphic fragment has a relative mobility of 4.2 kb and is associated with an HLA-A2,Cw*1401,B51,DR9,DR53,DQ9 haplotype. Nucleotide sequence analysis indicates that individuals showing this RFLP pattern do not carry a new DQA1 allele, but that (DQA1*0302) commonly observed in DR9,DQ9 haplotypes. The new RFLP seems to be a locally restricted marker of uncertain origin.

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Available abstract

Key concepts: TaqI, Restriction fragment length polymorphism, Haplotype, Genetics, Allele, Fragment (logic), HLA-DQ, Human leukocyte antigen