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1971•Annals of Internal MedicineRequires access

Failure of Methylene Blue Treatment in Toxic Methemoglobinemia

Peter J. Rosen, Cage S. Johnson, William McGehee, Ernest Beutler

Open publisher page 157 citations

Abstract

A patient who ingested an aniline-containing material developed severe methemoglobinemia. The usual beneficial response from administering methylene blue was not obtained, and within 24 hours a marked hemolytic episode occurred. The patient was found to be glucose-6-phosphate dehydrogenase-deficient and was therefore unable to utilize methylene blue in the NADPH-dependent reduction of methemoglobin. The possible role of methylene blue in precipitating the hemolysis is also discussed.

About this research paper

What this paper is about

A patient who ingested an aniline-containing material developed severe methemoglobinemia. The usual beneficial response from administering methylene blue was not obtained, and within 24 hours a marked hemolytic episode occurred. The patient was found to be glucose-6-phosphate dehydrogenase-deficient and was therefore unable to utilize methylene blue in the NADPH-dependent reduction of methemoglobin. The possible role of methylene blue in precipitating the hemolysis is also discussed.

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OpenAlex reports 157 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A patient who ingested an aniline-containing material developed severe methemoglobinemia. The usual beneficial response from administering methylene blue was not obtained, and within 24 hours a marked hemolytic episode occurred. The patient was found to be glucose-6-phosphate dehydrogenase-deficient and was therefore unable to utilize methylene blue in the NADPH-dependent reduction of methemoglobin. The possible role of methylene blue in precipitating the hemolysis is also discussed.

Key concepts: Methemoglobinemia, Methylene blue, Methemoglobin, Medicine, Hemolysis, Heinz body, Methylene, Hemoglobin

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