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STUDIES OF CERTAIN ANTIHISTAMINES AS ANTAGONISTS OF THE HYPERTENSIVE AND ANGIOTOXIC PROPERTIES OF DESOXYCORTICOSTERONE ACETATE IN THE RAT

Floyd R. Skelton

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Abstract

Three antihistamine agents, Phenergan, Benzodionole, and Trimeton have been studied for their ability to antagonize the hypertensive and cardiovascular-renal effects of desoxycorticosterone acetate in the unilaterally-nephrectomized, salt-treated, castrate male rat. In the order named all compounds produced only slight inhibition of the hypertensive and cardiotrophic action of desoxycorticosterone acetate and afforded virtually no protection against either the nephrotrophic or angiotoxic effects of this steroid as seen in the kidney, heart, and pancreatic, arterioles.

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What this paper is about

Three antihistamine agents, Phenergan, Benzodionole, and Trimeton have been studied for their ability to antagonize the hypertensive and cardiovascular-renal effects of desoxycorticosterone acetate in the unilaterally-nephrectomized, salt-treated, castrate male rat. In the order named all compounds produced only slight inhibition of the hypertensive and cardiotrophic action of desoxycorticosterone acetate and afforded virtually no protection against either the nephrotrophic or angiotoxic effects of this steroid as seen in the kidney, heart, and pancreatic, arterioles.

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Available abstract

Three antihistamine agents, Phenergan, Benzodionole, and Trimeton have been studied for their ability to antagonize the hypertensive and cardiovascular-renal effects of desoxycorticosterone acetate in the unilaterally-nephrectomized, salt-treated, castrate male rat. In the order named all compounds produced only slight inhibition of the hypertensive and cardiotrophic action of desoxycorticosterone acetate and afforded virtually no protection against either the nephrotrophic or angiotoxic effects of this steroid as seen in the kidney, heart, and pancreatic, arterioles.

Key concepts: Desoxycorticosterone Acetate, Antihistamine, Endocrinology, Chemistry, Internal medicine, Pharmacology, Medicine

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STUDIES OF CERTAIN ANTIHISTAMINES AS ANTAGONISTS OF THE HYPERTENSIVE AND ANGIOTOXIC PROPERTIES OF DESOXYCORTICOSTERONE ACETATE IN THE RAT — Research Paper | ScholarLens