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2011•Nano LettersRequires access

Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes

Robert Vácha, Francisco J. Martínez‐Veracoechea, Daan Frenkel

Open publisher page 496 citations

Abstract

Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.

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What this paper is about

Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.

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OpenAlex reports 496 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.

Key concepts: Endocytosis, Receptor-mediated endocytosis, Nanomedicine, Nanoparticle, Nanotechnology, Biophysics, Membrane, Chemistry

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