2003•The Journal of Organic ChemistryRequires access

Structure−Activity Relationship Studies of Illudins: Analogues Possessing a Spiro-cyclobutane Ring

Trevor C. McMorris, Qiang Cong, Michael J. Kelner

Abstract

Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.

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Key concepts: Cyclobutane, Cyclopropane, Chemistry, Bicyclic molecule, Stereochemistry, Sesquiterpene, Ring (chemistry), Tricyclic