2013European Journal of Clinical PharmacologyOpen access

Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia

Patricia Wennerstrand, Lars‐Göran Mårtensson, Stefan Söderhäll, Anna Zimdahl, Malin Lindqvist Appell

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Key concepts: Thiopurine methyltransferase, Methotrexate, Pharmacology, Enzyme assay, Enzyme, Toxicity, Medicine, Methyltransferase

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Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia — Research Paper | ScholarLens