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2006•Analytical LettersRequires access

A Fluorescence Spot Test for Salicylate Determination

Elisângela M. Linares, L. T. Palermo, Altair Benedito Moreira, Marı́a Del Pilar Taboada Sotomayor, Lauro T. Kubota

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Abstract

A procedure based on a spot test for salicylate is presented. The method is simple, rugged and is based on the salycilate native fluorescence measurement on the surface of a filter paper by using optical fibers for light conduction. The fluorescence was linear at concentration range of 0.01–0.4 mmol l−1. The relative standard deviation of 5% (n=10) was observed. Detection and quantification limits were 4 and 14 µmol l−1, respectively. The results obtained in pharmaceutical salicylate determinations showed that practically no statistical difference existed with the pharmacopeical method (95% confidence level). The recovery studies in biological samples spiked with salicylic acid at overdose concentration levels showed that the matrix sample did not interfere in the method.

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What this paper is about

A procedure based on a spot test for salicylate is presented. The method is simple, rugged and is based on the salycilate native fluorescence measurement on the surface of a filter paper by using optical fibers for light conduction. The fluorescence was linear at concentration range of 0.01–0.4 mmol l−1. The relative standard deviation of 5% (n=10) was observed. Detection and quantification limits were 4 and 14 µmol l−1, respectively. The results obtained in pharmaceutical salicylate determinations showed that practically no statistical difference existed with the pharmacopeical method (95% confidence level). The recovery studies in biological samples spiked with salicylic acid at overdose concentration levels showed that the matrix sample did not interfere in the method.

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Available abstract

A procedure based on a spot test for salicylate is presented. The method is simple, rugged and is based on the salycilate native fluorescence measurement on the surface of a filter paper by using optical fibers for light conduction. The fluorescence was linear at concentration range of 0.01–0.4 mmol l−1. The relative standard deviation of 5% (n=10) was observed. Detection and quantification limits were 4 and 14 µmol l−1, respectively. The results obtained in pharmaceutical salicylate determinations showed that practically no statistical difference existed with the pharmacopeical method (95% confidence level). The recovery studies in biological samples spiked with salicylic acid at overdose concentration levels showed that the matrix sample did not interfere in the method.

Key concepts: Chemistry, Salicylic acid, Detection limit, Chromatography, Fluorescence, Relative standard deviation, Methyl salicylate, Analytical Chemistry (journal)

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