Technetium‐99m human serum albumin in the differentiation of cerebrovascular and neoplastic lesions

Abstract Technetium‐99m pertechnetate and technetium‐99m human serum albumin have been used within a 24‐hr interval to evaluate the vascularity of abnormalities detected on routine technetium‐99m pertechnetate brain scans. Human serum albumin tagged with technetium‐99m has provided superior resolution of vascular lesions on static images but offered no advantage over technetium‐99m pertechnetate for early static imaging of neoplastic lesions. The use of technetium‐99m human serum albumin in the resolution of suspicious areas observed on routine technetium‐99m pertechnetate static scans is advised because it (1) more accurately detects vascular lesions, (2) serves better to indicate their total vascularity, and (3) will differentiate vascular lesions from neoplastic lesions.