1971•The Journal of AntibioticsOpen access

THE SPECTROPHOTOMETRIC DETERMINATION OF 5-METHYL-3-(2, 6-HALOGEN SUBSTITUTED PHENYL)-4-ISOXAZOLYL PENICILLINS (CLOXACILLN, DICLOXACILLIN AND FLUCLOXACILLIN)

Tsutomu Yasuda, SHIGEYUKI SHIMADA

Abstract

A method is described for the determination of 5-methyl-3-(2, 6-halogen substituted phenyl)-4-isoxazolyl penicillins (cloxacillin, dicloxacillin and flucloxacillin) by measuring the absorbance at 338-340 mμ of penicillenic acid formed on heating at 70°C in pH 2.0 buffer solution with copper as a catalyst. The results obtained with samples of cloxacillin, dicloxacillin and flucloxacillin are in good agreement with those obtained by biological assay.

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Key concepts: Flucloxacillin, Dicloxacillin, Cloxacillin, Chemistry, Chromatography, Absorbance, Halogen, Nuclear chemistry