1985•ScienceOpen access

Trans Activation of the Bovine Leukemia Virus Long Terminal Repeat in BLV-Infected Cells

C A Rosen, Joseph Sodroski, Richard Kettman, Arsène Burny, William A. Haseltine

Abstract

The transcription initiation signals for retroviruses lie within the long terminal repeat (LTR) sequences that flank the integrated provirus. This study shows that factors present in cells infected with bovine leukemia virus (BLV) mediate transcriptional trans activation of the BLV LTR. This phenomenon is similar to that reported for the human T-cell leukemia virus LTR and establishes both structural and functional criteria for inclusion of BLV and human T-cell leukemia viruses in the same family of transforming retroviruses.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 106 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Bovine leukemia virus, Provirus, Long terminal repeat, Virology, Biology, Leukemia, Virus, Deltaretrovirus