1987•AIDS Research and Human RetrovirusesRequires access

Activity of Interferons Alpha, Beta, and Gamma Against Human Immunodeficiency Virus Replication In Vitro

Kevan L. Hartshorn, DAVID NEUMEYER, Markus W. Vogt, Robert Turner Schooley, Martin Hirsch

Abstract

The antiviral activities of various interferon preparations against human immunodeficiency virus (HIV) were evaluated in vitro. Recombinant interferon alpha-A, and beta interferons and leukocyte-derived alpha interferons show similar concentration-dependent antiviral activity. Recombinant and lymphocyte-derived gamma interferons show minimal antiviral activity against HIV replication in normal peripheral blood mononuclear cells, but definite activity against HIV in the H9 lymphocytic and U937 monocyte-macrophage cell lines.

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Key concepts: Virology, Recombinant DNA, Peripheral blood mononuclear cell, In vitro, Monocyte, Biology, Virus, Alpha interferon