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2012•Unpublished venueRequires access

TGF-Beta and CTGF Mediated Signal Transduction Pathway and Fibrosis

Jingrui Tian, Yang Fang, Huiqin Liu

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Abstract

Transforming growth factor-beta (TGF-β) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor (CTGF) is considered to be the downstream factor of TGF-β, mediates fibrosis of TGF-β. TGF-β induces the expression of CTGF through multiple signal transduction pathways in promoting fibrosis. This article provides a brief summary of the research progress in this area.

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What this paper is about

Transforming growth factor-beta (TGF-β) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor (CTGF) is considered to be the downstream factor of TGF-β, mediates fibrosis of TGF-β. TGF-β induces the expression of CTGF through multiple signal transduction pathways in promoting fibrosis. This article provides a brief summary of the research progress in this area.

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OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Transforming growth factor-beta (TGF-β) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor (CTGF) is considered to be the downstream factor of TGF-β, mediates fibrosis of TGF-β. TGF-β induces the expression of CTGF through multiple signal transduction pathways in promoting fibrosis. This article provides a brief summary of the research progress in this area.

Key concepts: CTGF, Signal transduction, Transforming growth factor, Transforming growth factor beta, Connective tissue, Fibrosis, Growth factor, Cell biology

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