2006Molecular TherapyOpen access

32. Improvement of Muscle Mass Using shRNA Targeting Myostatin or Activin Receptor IIb

Julie Dumonceaux, Solenne Marie, Luis Garcı́a

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Abstract

Duchenne Muscular Dystrophy (DMD) is the most severe degenerative disorder of skeletal and cardiac muscle. DMD patients show a progressive muscle weakness which begins in early childhood. Our goal is to stop this continuous muscle wasting.

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Duchenne Muscular Dystrophy (DMD) is the most severe degenerative disorder of skeletal and cardiac muscle. DMD patients show a progressive muscle weakness which begins in early childhood. Our goal is to stop this continuous muscle wasting.

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Available abstract

Duchenne Muscular Dystrophy (DMD) is the most severe degenerative disorder of skeletal and cardiac muscle. DMD patients show a progressive muscle weakness which begins in early childhood. Our goal is to stop this continuous muscle wasting.

Key concepts: Myostatin, Activin receptor, ACVR2B, Follistatin, Small hairpin RNA, Activin type 2 receptors, Receptor, Cell biology

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