1988•Journal of Pharmacy and PharmacologyRequires access

Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.

E. A. Formukong, A.T. Evans, Fred J. Evans

Abstract

Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 21 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Cannabinol, Cannabidiol, Catalepsy, Cannabis sativa, Tetrahydrocannabinol, Pharmacology, Cannabis, Dronabinol