Antibodies to Enteroviruses in Hypogammaglobulinemic Patients

PATIENTS with acquired or congenital hypogammaglobulinemia usually lack detectable circulating antibody but are generally resistant to second attacks of the viral diseases that are considered to confer long lasting immunity.1 One explanation for such acquired immunity in hypogammaglobulinemia is the production of extremely low levels of circulating antibody. This paper reports the detection of what appears to be low levels of naturally acquired neutralizing antibody to enteroviruses in 2 patients with congenital hypogammaglobulinemia and 5 patients with acquired hypogammaglobulinemia.Materials and MethodsSerums, after heating for thirty minutes at 56°C, were tested for antibodies to Type 1 Mahoney, Type 2 . . .