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2012•Chemistry LettersRequires access

Cleavage of Supercoiled Plasmid DNA by Phenanthroline–Polyamine Conjugates as a Metal-free Artificial Nuclease

Tomokazu Masuda, Takeshi Sasagase, Akiko Ozaki, Masayasu Kuwahara, Hiroaki Ozaki, Hiroaki Sawai

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Abstract

Abstract In this study, phenanthroline–polyamine conjugates have been synthesized. The conjugates bind to DNA and hydrolyze it in the absence of any metal and reducing agent under physiological conditions.

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What this paper is about

Abstract In this study, phenanthroline–polyamine conjugates have been synthesized. The conjugates bind to DNA and hydrolyze it in the absence of any metal and reducing agent under physiological conditions.

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OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Abstract In this study, phenanthroline–polyamine conjugates have been synthesized. The conjugates bind to DNA and hydrolyze it in the absence of any metal and reducing agent under physiological conditions.

Key concepts: Chemistry, Polyamine, Nuclease, Phenanthroline, Conjugate, Cleavage (geology), DNA, Plasmid

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Cleavage of Supercoiled Plasmid DNA by Phenanthroline–Polyamine Conjugates as a Metal-free Artificial Nuclease — Research Paper | ScholarLens