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2004•Journal of Chinese Integrative MedicineRequires access

Comparison of animal models of hyperlipidemia

Xuemei Liu

Open publisher page 13 citations

Abstract

OBJECTIVE: To select the proper experimental animal model for research on prevention and treatment of hyperlipidemia. METHOD: Hyperlipidemia models of mouse, rat, golden hamster, guinea pig, rabbit, pigeon and quail often used in the last ten years were compared. RESULTS: Golden hamster and guinea pig models are similar to human beings in lipid metabolism and have unique superiority in experimental study, while the models of rat, mouse, pigeon and quail have significant difference as compared with human beings. Rabbit is one of the best animal models in studying new drugs for regulating lipid and treating arteriosclerosis. CONCLUSION: Factors such as the required time, indexes, the duration of making models, and the cost and feeding of animals should be considered in selecting animal models according with the experimental requirements.

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What this paper is about

OBJECTIVE: To select the proper experimental animal model for research on prevention and treatment of hyperlipidemia. METHOD: Hyperlipidemia models of mouse, rat, golden hamster, guinea pig, rabbit, pigeon and quail often used in the last ten years were compared. RESULTS: Golden hamster and guinea pig models are similar to human beings in lipid metabolism and have unique superiority in experimental study, while the models of rat, mouse, pigeon and quail have significant difference as compared with human beings. Rabbit is one of the best animal models in studying new drugs for regulating lipid and treating arteriosclerosis. CONCLUSION: Factors such as the required time, indexes, the duration of making models, and the cost and feeding of animals should be considered in selecting animal models according with the experimental requirements.

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Available abstract

OBJECTIVE: To select the proper experimental animal model for research on prevention and treatment of hyperlipidemia. METHOD: Hyperlipidemia models of mouse, rat, golden hamster, guinea pig, rabbit, pigeon and quail often used in the last ten years were compared. RESULTS: Golden hamster and guinea pig models are similar to human beings in lipid metabolism and have unique superiority in experimental study, while the models of rat, mouse, pigeon and quail have significant difference as compared with human beings. Rabbit is one of the best animal models in studying new drugs for regulating lipid and treating arteriosclerosis. CONCLUSION: Factors such as the required time, indexes, the duration of making models, and the cost and feeding of animals should be considered in selecting animal models according with the experimental requirements.

Key concepts: Hamster, Hyperlipidemia, Animal model, Quail, Experimental animal, Guinea pig, Animal species, Golden hamster

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