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1987•Acta Chimica SinicaRequires access

Studies on the mass spectrometry of natural products: V. Negative ion fast atom bombardment and collisional activation mass spectrometry in the structural analysis of oligoglycosides

Nengyu Chen, Ning Chen, Hong Li, Yaozu Chen, Zhao Fang-Zhi, Chang‐Xiang Chen, Yang Chong-Ren

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Abstract

The negative ion fast atom bombardment (NFAB) mass spectrometry of eight glycosides containing one to three sugar units have been studied. The mass spectra of NFAB exhibit more predominant quasi-molecular ions without adduct ions in the high mass region, which indicate more unambiguously the molecular weights of the glycosides, than the positive ion FAB (PFAB) spectra do. Among the three matrix substances tested, glycerol, thioglycerol and PEG-200, the last one was found to give the best results. The characteristic ions of NFAB collisional activation (NFAB-CA) spectra of [M-H]− ions were more abundant and gave more definite information about sequences of the sugar units than the corresponding PFAB-CA spectra of [M + H]+ ions.

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What this paper is about

The negative ion fast atom bombardment (NFAB) mass spectrometry of eight glycosides containing one to three sugar units have been studied. The mass spectra of NFAB exhibit more predominant quasi-molecular ions without adduct ions in the high mass region, which indicate more unambiguously the molecular weights of the glycosides, than the positive ion FAB (PFAB) spectra do. Among the three matrix substances tested, glycerol, thioglycerol and PEG-200, the last one was found to give the best results. The characteristic ions of NFAB collisional activation (NFAB-CA) spectra of [M-H]− ions were more abundant and gave more definite information about sequences of the sugar units than the corresponding PFAB-CA spectra of [M + H]+ ions.

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Available abstract

The negative ion fast atom bombardment (NFAB) mass spectrometry of eight glycosides containing one to three sugar units have been studied. The mass spectra of NFAB exhibit more predominant quasi-molecular ions without adduct ions in the high mass region, which indicate more unambiguously the molecular weights of the glycosides, than the positive ion FAB (PFAB) spectra do. Among the three matrix substances tested, glycerol, thioglycerol and PEG-200, the last one was found to give the best results. The characteristic ions of NFAB collisional activation (NFAB-CA) spectra of [M-H]− ions were more abundant and gave more definite information about sequences of the sugar units than the corresponding PFAB-CA spectra of [M + H]+ ions.

Key concepts: Chemistry, Fast atom bombardment, Mass spectrometry, Mass spectrum, Ion, Mass, Adduct, Analytical Chemistry (journal)

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Studies on the mass spectrometry of natural products: V. Negative ion fast atom bombardment and collisional activation mass spectrometry in the structural analysis of oligoglycosides — Research Paper | ScholarLens