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1997•Cellular Physiology and BiochemistryRequires access

Contribution of Ca2+-Activated K+ Channels to the Enhancement of the Secondary Immune Response

Jos A. H. Verheugen

Open publisher page 3 citations

Abstract

The expression of ion channels in human T lymphocytes changes with the activation state of the cell. In particular the density of a Ca2+-activated K+ [K(Ca)] channel increases dramatically in the first days following activation by T cell receptor (TCR) stimulation. The experiments reviewed in this article show how this channel contributes to an enhancement of the secondary immune response, by mediating positive feedback between Ca2+ influx and membrane hyperpolarization during the Ca2+-response upon TCR restimulation.

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What this paper is about

The expression of ion channels in human T lymphocytes changes with the activation state of the cell. In particular the density of a Ca2+-activated K+ [K(Ca)] channel increases dramatically in the first days following activation by T cell receptor (TCR) stimulation. The experiments reviewed in this article show how this channel contributes to an enhancement of the secondary immune response, by mediating positive feedback between Ca2+ influx and membrane hyperpolarization during the Ca2+-response upon TCR restimulation.

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Available abstract

The expression of ion channels in human T lymphocytes changes with the activation state of the cell. In particular the density of a Ca2+-activated K+ [K(Ca)] channel increases dramatically in the first days following activation by T cell receptor (TCR) stimulation. The experiments reviewed in this article show how this channel contributes to an enhancement of the secondary immune response, by mediating positive feedback between Ca2+ influx and membrane hyperpolarization during the Ca2+-response upon TCR restimulation.

Key concepts: T-cell receptor, Hyperpolarization (physics), Immune system, Stimulation, Chemistry, T cell, Ion channel, Biophysics

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