1980•The Japanese Journal of PharmacologyOpen access

The suppressive effect of hepatic 9,000*g supernatant fraction from 3-methylcholanthrene-treated rats on the mutagenic activity of 2-acetylaminofluorene.

Akie Kojima, Sumie KAWANO, Kogo Hiraga

Abstract

Hepatic 9,000 x g supernatant (S9) fraction from 3-methylcholanthrene (MC)-treated rats showed a significantly low activity in the in vitro conversion of 2-acetylaminofluorene (AAF) to mutagen(s), while S9 fraction from untreated or phenobarbital (PB)-treated rats showed a remarkable activity. The S9 fraction from MC-treated rats actually suppressed the PB-S9 mediated AAF mutagenicity. Since the suppressive effect of MC-S9 was lost by the addition of 10(-4) M alpha-naphthoflavone (alpha-NF), rat specific cytochrome P-448 may be responsible for this suppressive effect.

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Key concepts: 2-Acetylaminofluorene, Methylcholanthrene, Phenobarbital, Chemistry, In vitro, S9 fraction, Fraction (chemistry), Mutagen