2009•F1000 Biology ReportsOpen access

Osmolyte solutions and protein folding

Char Hu, B. Montgomery Pettitt, Joerg Roesgen

Abstract

In this brief review we discuss the evolution of recent thought regarding the role and mechanism of osmolytes with respect to protein stability. Osmolytes are naturally occurring intracellular compounds that change the protein folding landscape. Contributions from experiments are considered in the context of current theory and simulation results.

Open-access reader

About this research paper

What this paper is about

Why it matters

OpenAlex reports 19 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Osmolyte, Protein folding, Protein stability, Folding (DSP implementation), Context (archaeology), Mechanism (biology), Chemistry, Computational biology