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2008•Chinese Journal of ChemistryRequires access

L‐Proline‐based Phosphamides as a New Kind of Organocatalyst for Asymmetric Direct Aldol Reactions

Yu Guo, Zemei Ge, Tieming Cheng, Runtao Li

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Abstract

Abstract Four L‐proline‐based phosphamides were designed and synthesized as a new kind of organocatalyst. Their catalytic activities for asymmetric direct aldol reactions were evaluated. Among them, 3a with 10 mol% catalyst loading afforded moderate to good yields and up to 99% ee.

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Abstract Four L‐proline‐based phosphamides were designed and synthesized as a new kind of organocatalyst. Their catalytic activities for asymmetric direct aldol reactions were evaluated. Among them, 3a with 10 mol% catalyst loading afforded moderate to good yields and up to 99% ee.

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Available abstract

Abstract Four L‐proline‐based phosphamides were designed and synthesized as a new kind of organocatalyst. Their catalytic activities for asymmetric direct aldol reactions were evaluated. Among them, 3a with 10 mol% catalyst loading afforded moderate to good yields and up to 99% ee.

Key concepts: Chemistry, Aldol reaction, Proline, Organocatalysis, Catalysis, Organic chemistry, Combinatorial chemistry, Enantioselective synthesis

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