2010•BIOPHYSICSRequires access

Fluorescence of acridine orange in the composition of blood and tissues

Eldar N. Kurtaliev, Negmat Nizomov, Sh. N. Nizamov, Feruza U. Khaydarova, Gayrat Khodjayev

Abstract

The interaction of acridine orange with blood albumins and tissue cells from different organs of white mouse has been studied by the spectral luminescence method. It was shown that acridine orange, by penetrating cells or orangelles, is able to intercalate between base pairs in the DNA molecule. It was found that the application of acridine orange as a fluorescent probe can influence the metabolic activity of organs.

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Available abstract

Key concepts: Acridine orange, Acridine, Fluorescence, Orange (colour), Chemistry, Intercalation (chemistry), DNA, Biophysics