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SUMMARY OF CHEMOTHERAPEUTIC STUDIES IN EXPERIMENTAL TRYPANOSOMIASIS

JAY FRANK SCHAMBERG

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Abstract

METHOD OF STUDY 1. Therapeutic Experiments. —In our investigations, the following four parasites were employed: theSpirochaeta recurrentis(the parasite of relapsing fever), theTrypanosoma brucei(the parasite of Nagana disease of horses), theTrypanosoma lewisi(a saphrophytic parasite in rats), andTrypanosoma equiperdum(the parasite of la dourine or horse syphilis). Inasmuch as the influence of the drug administered on the duration of life of the infected animals was one of the important criteria of its efficiency, we found theTrypanosoma lewisiunsatisfactory because it does not as a rule kill the animal. The spirochete of relapsing fever led to confusing results because of the frequent remissions and the disappearance of the parasite from the peripheral blood. TheTrypanosoma bruceikilled rats within a few days, a period too short to study the effects of the weaker agents. TheTrypanosoma equiperdumwas found admirably adapted to the purposes of

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METHOD OF STUDY 1. Therapeutic Experiments. —In our investigations, the following four parasites were employed: theSpirochaeta recurrentis(the parasite of relapsing fever), theTrypanosoma brucei(the parasite of Nagana disease of horses), theTrypanosoma lewisi(a saphrophytic parasite in rats), andTrypanosoma equiperdum(the parasite of la dourine or horse syphilis). Inasmuch as the influence of the drug administered on the duration of life of the infected animals was one of the important criteria of its efficiency, we found theTrypanosoma lewisiunsatisfactory because it does not as a rule kill the animal. The spirochete of relapsing fever led to confusing results because of the frequent remissions and the disappearance of the parasite from the peripheral blood. TheTrypanosoma bruceikilled rats within a few days, a period too short to study the effects of the weaker agents. TheTrypanosoma equiperdumwas found admirably adapted to the purposes of

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Available abstract

METHOD OF STUDY 1. Therapeutic Experiments. —In our investigations, the following four parasites were employed: theSpirochaeta recurrentis(the parasite of relapsing fever), theTrypanosoma brucei(the parasite of Nagana disease of horses), theTrypanosoma lewisi(a saphrophytic parasite in rats), andTrypanosoma equiperdum(the parasite of la dourine or horse syphilis). Inasmuch as the influence of the drug administered on the duration of life of the infected animals was one of the important criteria of its efficiency, we found theTrypanosoma lewisiunsatisfactory because it does not as a rule kill the animal. The spirochete of relapsing fever led to confusing results because of the frequent remissions and the disappearance of the parasite from the peripheral blood. TheTrypanosoma bruceikilled rats within a few days, a period too short to study the effects of the weaker agents. TheTrypanosoma equiperdumwas found admirably adapted to the purposes of

Key concepts: Trypanosoma brucei, Parasite hosting, Trypanosomiasis, Biology, Trypanosoma, Trypanosoma evansi, African trypanosomiasis, Virology

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