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Protection of Cattle Against Rinderpest with Vaccinia Virus Recombinants Expressing the HA or F Gene

Tilahun Yilma, David S. Hsu, Leslie Jones, Sally Owens, Marvin J. Grubman, Charles A. Mebus, Miles K. Yamanaka, Beverly A. Dale

Open publisher page 141 citations

Abstract

Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.

About this research paper

What this paper is about

Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.

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OpenAlex reports 141 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.

Key concepts: Rinderpest virus, Rinderpest, Virology, Vaccinia, Biology, Virus, Hemagglutinin (influenza), Poxviridae

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