2007•Nucleosides Nucleotides & Nucleic AcidsRequires access

NewCycloAMB-Nucleoside Phosphonate Prodrugs

Ulf Görbig, Jan Balzarini, Chris Meier

Abstract

cycloSal- and cycloAmb-nucleoside phosphonate prodrugs of PMEA were synthesized and characterized. Each of these compounds showed different disadvantages in hydrolysis. Thus, a new series of cycloAminobenzyl(cycloAmb)-PMEA prodrugs was synthezised and studied with regard to their hydrolysis properties and biological activity.

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Available abstract

Key concepts: Prodrug, Phosphonate, Nucleoside, Hydrolysis, Chemistry, Stereochemistry, Combinatorial chemistry, Biochemistry