1993•Journal of NeuroendocrinologyRequires access

Galanin‐Induced Growth Hormone Secretion in Conscious Rats: Evidence for a Possible Involvement of Somatostatin

Tsutomu Tanoh, Akira Shimatsu, Yasuhiro Ishikawa, Chihiro Ihara, Noboru Yanaihara, Hiroo Imura

Abstract

Intracerebroventricular administration of galanin (GAL) potently evoked growth hormone (GH) secretion in conscious male rats. Pretreatments with neostigmine and cysteamine blunted the GAL-induced GH secretion. Pretreatment of animals with a specific anti-somatostatin serum significantly inhibited the GAL-induced GH secretion. On the contrary, GH-releasing hormone-induced GH secretion was significantly enhanced with cysteamine and anti-somatostatin serum. These results suggest that somatostatin is involved in GAL-induced GH secretion in rats.

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Key concepts: Somatostatin, Endocrinology, Internal medicine, Galanin, Secretion, Growth hormone, Neuropeptide, Hormone