Effect of polychlorinated biphenyl, dibenzofuran and dibenzo‐p‐dioxin on the susceptibility of male mice to endotoxin
Shogo Oishi, K. Hiraga
Abstract
Shogo Oishi, K. Hiraga
Abstract
The effect of polychlorinated biphenyl (PCB), dibenzofuran (CDF) and dibenzo-p-dioxin (CDD) on endotoxin sensitivity was studied in male mice. The oral administration of CDF and CDD, once a week for 4 weeks, increased endotoxin sensitivity, whereas, PCB was not affective. On the other hand, residual levels of PCB were detected in thymus but CDF and CDD were not.
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The effect of polychlorinated biphenyl (PCB), dibenzofuran (CDF) and dibenzo-p-dioxin (CDD) on endotoxin sensitivity was studied in male mice. The oral administration of CDF and CDD, once a week for 4 weeks, increased endotoxin sensitivity, whereas, PCB was not affective. On the other hand, residual levels of PCB were detected in thymus but CDF and CDD were not.
Key concepts: Dibenzofuran, Polychlorinated biphenyl, Biphenyl, Chemistry, Internal medicine, Pharmacology, Toxicology, Environmental chemistry