2009•DigestionRequires access

Dose-Response Studies of Gastric Pepsin Secretion in Man after Stimulation with Pentagastrin

Per Aagaard, John Christiansen

Abstract

In 5 patients with duodenal ulcer the secretion of pepsin following a continuous intravenous infusion of pentagastrin in a dose of 0.005, 0.01, 0.1 and 0.2 μg/kg/min has been investigated. In every exanimation the stimulation was continued for 2½ h, and the examinations were carried out on different days. The maximal secretion of pepsin was found after a dose of pentagastrin of 0.1 μg/kg/min.

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Key concepts: Pentagastrin, Pepsin, Internal medicine, Stimulation, Secretion, Endocrinology, Medicine, Gastric secretion